Potential synergism between wheat bran and psyllium: enhanced inhibition of colon cancer.
Cancer Lett
; 75(1): 53-8, 1993 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-8287381
ABSTRACT
In this study we compared the influence of high fat (20% w/w) diets that combine low levels of calcium (0.18% w/w) and low (1% w/w), medium (4% w/w) and high (8% w/w) levels of dietary fiber from wheat bran (WB), with high (8% w/w) levels of dietary fiber from psyllium (PS) alone or in various combinations with WB, on the induction of colon tumors in Fischer-344 rats following exposure to azoxymethane (AOM). The rats were fed the experimental diets for 2 weeks, and then were given two s.c. injections of AOM (15 mg/kg body wt./week). Twenty-three weeks following the first injection of AOM, the incidence of colon tumors in the different dietary groups (12 rats/group) was compared. The results clearly showed that by increasing the dietary fiber concentration of WB from 1 to 8% significantly reduced the number of colon tumors/group. When the influence of 8% dietary fiber from WB on the development of colon tumors was compared with that of PS (WBPS = 0100), no significant difference was observed. However, combinations of WB and PS showed a greater protective effect than either WB or PS alone, at comparable levels of dietary fiber. The 5050 combination of WB and PS showed maximum protection, while 2575 and 7525 combinations both produced intermediate effects. None of the diets showed any significant effect on the normal growth of rats. The results indicate that WB and PS fiber alone, and to a greater degree in combination, can offer protection against colon cancer promoted by high fat, low calcium diets. Diets that include wheat bran in combination with psyllium could be an effective means of reducing colon cancer risk in human populations addicted to high risk western diets.
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Base de dados:
MEDLINE
Assunto principal:
Psyllium
/
Fibras na Dieta
/
Neoplasias do Colo
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1993
Tipo de documento:
Article