Pro- and anti-inflammatory cytokines in primary systemic vasculitis.

Kekow, J; Szymkowiak, C H; Sticherling, M; Schröder, J M; Christophers, E; Gross, W L

Kekow, J; Szymkowiak, C H; Sticherling, M; Schröder, J M; Christophers, E; Gross, W L.

Afiliação

Kekow J; Department of Clinical Rheumatology, Medical University at Lübeck, Germany.

Adv Exp Med Biol ; 336: 341-4, 1993.

Article em En | MEDLINE | ID: mdl-8296631

ABSTRACT

ABSTRACT

The expression of cytokines that are potentially involved in the pathogenesis of vasculitis was studied in patients with primary systemic vasculitis (PSV). In extension of earlier reports, we detected an overexpression of transforming growth factor beta (TGF beta), interleukin 6 (IL6), and interleukin 8 (IL8), indicating that the whole cytokine cascade is activated to a significant extent in PSV.

Assuntos

Citocinas/sangue; Vasculite/sangue; Síndrome de Churg-Strauss/sangue; Citocinas/genética; Expressão Gênica; Granulomatose com Poliangiite/sangue; Humanos; Interleucina-6/genética; Interleucina-6/metabolismo; Interleucina-8/genética; Interleucina-8/metabolismo; RNA Mensageiro/sangue; Fator de Crescimento Transformador beta/genética; Fator de Crescimento Transformador beta/metabolismo

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vasculite / Citocinas Limite: Humans Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Alemanha

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