Hyperphenylalanemia: effect on brain polyribosomes can be partially reversed by other amino acids.
Science
; 195(4276): 402-4, 1977 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-831283
ABSTRACT
The effect of a single injection of phenylalanine (2 mg/g of body weight) on brain polyribosomes, which increases the number of inactive monoribosomes, persists for 2 to 3 hours. A single injection of seven large neutral amino acids after phenylalanine administration results in a reversal of the effect on brain polyribosomes with a resultant decrease in monoribosomes to near normal levels. The other common amino acids are apparently not limiting during hyperphenylalanemia, because an injection of these did not increase recovery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Ribossomos
/
Encéfalo
/
Aminoácidos
Idioma:
En
Revista:
Science
Ano de publicação:
1977
Tipo de documento:
Article