Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam.
J Antimicrob Chemother
; 31(1): 89-103, 1993 Jan.
Article
em En
| MEDLINE
| ID: mdl-8383105
ABSTRACT
The activity of six cephalosporins, six penicillins and one monobactam combined with BRL 42715, clavulanic acid, sulbactam or tazobactam at 0.1, 0.5, 1, 2, 5 and 10 mg/L was determined for 45 beta-lactamase producing Gram-negative bacteria. The combination of BRL 42715 with any of the agents was more active than any of the other inhibitor and beta-lactam combinations. Unlike the other beta-lactamase inhibitors, BRL 42715 enhanced the activity of the beta-lactams for strains that constitutively expressed Richmond & Sykes Class I beta-lactamase and against strains expressing extended-spectrum plasmid-mediated beta-lactamases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamas
/
Quimioterapia Combinada
/
Inibidores de beta-Lactamases
/
Bactérias Gram-Negativas
/
Lactamas
/
Antibacterianos
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido