Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals.
Nature
; 364(6438): 635-9, 1993 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-8394510
ABSTRACT
Calcium influx through voltage-sensitive Ca2+ channels is the normal physiological stimulus for the activity-dependent release of neurotransmitters at synaptic contacts. It has been postulated that presynaptic inhibition of transmitter release is due to a reduction in Ca2+ influx at the nerve terminal, which could result from the direct inhibition of Ca2+ channels. Neuropeptide Y and noradrenaline act as cotransmitters at many sympathetic synapses. Both of these substances produce presynaptic inhibition and can inhibit Ca2+ currents in the soma of sympathetic neurons. Here we provide direct evidence that presynaptic inhibition produced by neuropeptide Y at sympathetic nerve terminals is associated with a reduction in Ca2+ influx and that this is due to the selective inhibition of neuronal N-type Ca2+ channels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Simpático
/
Neuropeptídeo Y
/
Canais de Cálcio
/
Terminações Nervosas
/
Inibição Neural
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
1993
Tipo de documento:
Article