EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.
Nat Genet
; 4(4): 341-5, 1993 Aug.
Article
em En
| MEDLINE
| ID: mdl-8401579
ABSTRACT
The genes involved in the t(12;22)(q13;q12) translocation found recurrently in malignant melanoma of soft parts have been characterized and shown to form, in four cases studied, hybrid transcripts. The deduced chimaeric protein encoded by the der(22) chromosome consists of the N-terminal domain of EWS linked to the bZIP domain of ATF-1, a transcription factor which may normally be regulated by cAMP. ATF-1 has not previously been implicated in oncogenesis. EWS was first identified as forming a hybrid transcript in Ewing's sarcoma, which links its N-terminal domain to the DNA binding domain of the FLI-1 gene. Thus the oncogenic conversion of EWS follows a common scheme of activation, exchanging its putative RNA binding domain with different DNA binding domains that appear to be tumour-specific.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Neoplasias de Tecidos Moles
/
Fatores de Transcrição
/
Translocação Genética
/
Cromossomos Humanos Par 12
/
Cromossomos Humanos Par 22
/
Proteínas de Fusão Oncogênica
/
Clonagem Molecular
/
Proteínas de Ligação a DNA
/
Melanoma
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
França