Identification of putative internalization signals in prion proteins.
FEBS Lett
; 331(1-2): 1-3, 1993 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-8405384
ABSTRACT
Prion proteins were found to contain regions in their cytoplasmic domains that have significant structural homologies to molecular trafficking signals for internalization of membrane proteins. These regions may facilitate the endocytosis of prion proteins, which appears to be a first step in their conversion to the abnormal, amyloidogenic form.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Príons
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1993
Tipo de documento:
Article