Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study.
J Neurol
; 240(7): 417-22, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8410082
ABSTRACT
A neurological surveillance was combined with prospective recording of upper respiratory and gastrointestinal infections and serological diagnosis of five common viral infections in 60 benign multiple sclerosis patients, with a mean follow-up of 31 months. During 4-week at risk (AR) periods encompassing common infections, a significant excess of MS relapses was found in the AR period, with a relative risk of 1.3. A seasonal variation of the MS relapse rate was found with a minimum in summer. There was a significant correlation between the number of AR relapses and the number of common infections per month explaining the periannual distribution of relapses. The non-AR relapses showed no seasonal variation. There was a significant correlation between adenovirus CF titre rises associated with upper respiratory infections and the occurrence of a major MS relapse in the AR period (n = 7), while influenza infections were not followed by a major MS relapse (n = 6). Linear homologies have been demonstrated between adenovirus and basic myelin protein. The epidemiological approach is essential to our understanding of systemic antigens triggering multiple sclerosis activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viroses
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
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Humans
/
Male
Idioma:
En
Revista:
J Neurol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Suécia