Embryotoxicity of the folate antagonist methotrexate in rats and rabbits.
Teratology
; 15(1): 73-9, 1977 Feb.
Article
em En
| MEDLINE
| ID: mdl-841483
ABSTRACT
The prenatal effects of methotrexate (MTX) in rats and rabbits were assessed. It was found highly embryotoxic in postimplantation rat embryos; 0.3 mg/kg ip or less caused nearly total embryolethality with slight teratogenicity. Rabbit embryos were far more resistant to small doses of MTX than rats, but 19.2 mg/kg iv, when given during days 10 to 15 of gestation, produced little death and a constant spectrum of malformation in a high percentage of offspring. Cleft palate, skull defects, and severe fore- and hindlimb dysplasias, occurred with a high degree of regularity and were strongly dose and developmental-stage specific.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Induzidas por Medicamentos
/
Metotrexato
/
Morte Fetal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Teratology
Ano de publicação:
1977
Tipo de documento:
Article