Liposomal drug delivery to the eye and lungs: a preliminary electron microscopy study.
J Microencapsul
; 10(1): 35-44, 1993.
Article
em En
| MEDLINE
| ID: mdl-8445506
ABSTRACT
Colloidal gold was used as an electron-dense marker for multilamellar vesicles to study the mechanism of liposome drug delivery to the eye and lung. A gold labelled multilamellar vesicle could be seen in the conjunctiva but there was no evidence of vesicles adsorbed to the epithelial surface of cornea or conjunctiva. In the lung, a free gold particle was isolated in type 1 epithelial cells and many vesicular structures were observed in the alveolar spaces which were not gold labelled. Experiments performed so far indicate that adsorption and not endocytosis was the major mechanism of uptake of drug or marker for multilamellar vesicles except for conjunctiva.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Olho
/
Lipossomos
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
J Microencapsul
Assunto da revista:
FARMACIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Canadá