T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.
J Exp Med
; 177(4): 1175-80, 1993 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-8459211
ABSTRACT
The role of T cells expressing specific V beta elements was examined in the regulation of allergen-specific immunoglobulin (Ig)E production and airways responsiveness (AR). In BALB/c mice, inhalation of the allergen ovalbumin (OVA) induced an IgE anti-OVA response, immediate cutaneous reactivity, and increased AR. These results were associated with an expansion of V beta 8.1/8.2 T cells in local draining lymph nodes of the airways and the lung. Transfer of V beta 8.1/8.2 T cells from sensitized mice stimulated an IgE anti-OVA response, immediate cutaneous hypersensitivity, and increased AR in naive syngeneic recipients. In contrast, OVA-reactive V beta 2 T cells inhibited these effects. These data demonstrate for the first time that T cells with different V beta specificities play a critical role in the in vivo regulation of allergen-specific IgE production and AR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Linfócitos T
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Receptores de Antígenos de Linfócitos T alfa-beta
/
Hiper-Reatividade Brônquica
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1993
Tipo de documento:
Article