Synthesis and pharmacological evaluation of (nitrooxy)alkyl apovincaminates.
J Med Chem
; 36(7): 815-9, 1993 Apr 02.
Article
em En
| MEDLINE
| ID: mdl-8464035
ABSTRACT
A series of (nitrooxy)alkyl apovincaminates has been synthesized and evaluated for their effects on vertebral and femoral blood flow. These derivatives were prepared from apovincaminic acid (4). In cerebral circulation, compound 5 (0.03-1.0 mg/kg iv) caused a dose-dependent increase in cerebral blood flow (CerBF) without affecting the blood pressure. It was more potent than vinpocetine (2). The structures of 2 and 5, determined by X-ray crystallography, showed differences in the electrostatic potential image and in the conformation of the ethyl group at the 16-position.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
/
Alcaloides de Vinca
/
Vincamina
/
Nitrocompostos
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão