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Anthracycline containing regimens in intermediate grade lymphoma. Italian Cooperative Study Group on Intermediate Grade Malignant Lymphoma.
Zinzani, P L; Tura, S; Cajozzo, A; Leone, G; Papa, G; Gentilini, P; Rossi, G; Aitini, E; Mandelli, F.
Afiliação
  • Zinzani PL; Institute of Hematology LeA Seràgnoli, Bologna, Italy.
Leuk Lymphoma ; 10 Suppl: 39-41, 1993.
Article em En | MEDLINE | ID: mdl-8481669
From March 1991 to April 1992, 44 previously untreated patients with stage II to IV intermediate-grade non-Hodgkin's lymphoma (according to the Kiel classification) were entered in a phase III comparative trial. The objectives of the study were to compare the efficacy and safety of using idarubicin instead of doxorubicin in the combination chemotherapeutic regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone). Forty-four patients were randomly assigned to receive either CI(idarubicin)OP or CH(doxorubicin)OP. The study is ongoing and so far no significant differences in complete response rate and (non-)hematologic toxicity have been observed.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Idarubicina / Protocolos de Quimioterapia Combinada Antineoplásica / Doxorrubicina Tipo de estudo: Clinical_trials Limite: Adult / Humans / Middle aged Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Itália
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma não Hodgkin / Idarubicina / Protocolos de Quimioterapia Combinada Antineoplásica / Doxorrubicina Tipo de estudo: Clinical_trials Limite: Adult / Humans / Middle aged Idioma: En Revista: Leuk Lymphoma Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 1993 Tipo de documento: Article País de afiliação: Itália