Accessory function and properties of monocytes from healthy elderly humans for T lymphocyte responses to mitogen and antigen.
Gerontology
; 39(2): 93-108, 1993.
Article
em En
| MEDLINE
| ID: mdl-8514204
ABSTRACT
The waning of cell-mediated immunity during aging has been attributed primarily to defects in T lymphocyte properties and functions. We assessed the potential contribution of accessory dysfunction of monocytes from the elderly on responses of T cells to phytohemagglutinin (PHA) and to tetanus toxoid after in vivo boosting. Accessory function of monocytes from the elderly subjects for T lymphocyte responses to tetanus toxoid was comparable to the young. Expression of the cytokines interleukin-1, interleukin-6 and tumor necrosis factor, the cell adhesion molecules ICAM-1 and LFA-3 and the class II major histocompatibility molecule HLA-DR by monocytes from the elderly and young subjects was similar. T lymphocytes from the elderly responded poorly to PHA. Monocytes from the elderly had a decreased accessory function for PHA-stimulated T cells from young, third donors. Thus, although many accessory properties of monocytes from the elderly are normal, the monocyte and T lymphocyte defects in the elderly for mitogen may represent interactive factors in cell-mediated immunity during aging.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fito-Hemaglutininas
/
Envelhecimento
/
Toxoide Tetânico
/
Monócitos
/
Linfócitos T
/
Células Apresentadoras de Antígenos
Limite:
Humans
Idioma:
En
Revista:
Gerontology
Ano de publicação:
1993
Tipo de documento:
Article