Action at a distance: DNA-looping and initiation of transcription.
Trends Biochem Sci
; 20(12): 500-6, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8571451
ABSTRACT
Effective initiation of transcription, especially in eukaryotes, requires the specific assembly of large protein complexes at promoters. We ask here how activator proteins that are bound hundreds or thousands of base pairs away from the promoter might facilitate this process if protein-protein interactions occur via looping of the intervening DNA. We show that the local concentration at the promoter of activator proteins bound at vicinal DNA sites can be substantially regulated by intrinsic or protein-induced distortion of the regular DNA conformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
DNA
/
Conformação de Ácido Nucleico
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Alemanha