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phoP/phoQ-deleted Salmonella typhi (Ty800) is a safe and immunogenic single-dose typhoid fever vaccine in volunteers.
Hohmann, E L; Oletta, C A; Killeen, K P; Miller, S I.
Afiliação
  • Hohmann EL; Infectious Disease Unit, Massachusetts General Hospital, Boston, USA.
J Infect Dis ; 173(6): 1408-14, 1996 Jun.
Article em En | MEDLINE | ID: mdl-8648213
The phoP/phoQ virulence regulatory genes of Salmonella typhi Ty2 were deleted, and the resultant strain (Ty800) was tested as a live attenuated typhoid fever vaccine in human volunteers. Groups of 2 or 3 subjects received single oral doses of 10(7), 10(8), 10(9), or 10(10) cfu. Two volunteers who received the largest dose had self-limited side effects; no bacteremias were detected. Ten of 11 subjects had evidence of intestinal immune responses to the vaccine as measured by increases in S. typhi lipopolysaccharide-specific IgA-secreting cells in peripheral blood samples. Humoral immune responses were measured and compared with those of control vaccinees who received 4 oral doses of S. typhi Ty21a. In the most sensitive assays, 9 of 11 volunteers and 5 of 8 Ty21a control vaccinees had evidence of IgG directed against S. typhi antigens. Ty800 is safe, and single oral doses are highly immunogenic in humans.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Salmonella typhi / Vacinas Tíficas-Paratíficas / Anticorpos Antibacterianos Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Salmonella typhi / Vacinas Tíficas-Paratíficas / Anticorpos Antibacterianos Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Estados Unidos