dup(10q) lacking alpha-satellite DNA in bone marrow cells of a patient with acute myeloid leukemia.
Cancer Genet Cytogenet
; 89(1): 1-6, 1996 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-8689602
ABSTRACT
A marker chromosome was identified in leukemic cells on an AML patient. The G-banding pattern resembled on i(10q), but its centromeric position was not clear; in some cells it had a telocentric shape, in others a metacentric or acentric shape. The origin of the marker chromosome was confirmed by FISH, using chromosome-10-specific painting. To determine the centromeric position, C-banding and alpha-satellite probes were applied in FISH, and none of them gave a positive signal. Despite the absence of the centromeric alpha-satellite sequences and the constricted feature of the centromere, the essential centromeric activity was retained in this chromosome, namely, the separation of sister chromatids in anaphase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 10
/
DNA Satélite
/
Leucemia Mieloide Aguda
/
Aberrações Cromossômicas
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Israel