Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid.
J Antimicrob Chemother
; 37(2): 383-7, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8707752
ABSTRACT
Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg valaciclovir, or 30 mL Maalox 65 min after valaciclovir administration, or 30 mL Maalox 30 min before valaciclovir. Acyclovir plasma concentrations and pharmacokinetic parameters were not significantly affected by administration of Maalox before or after valaciclovir. Therefore, there is no need for restriction of valaciclovir dosing in patients receiving antacid medication.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Valina
/
Aciclovir
/
Pró-Fármacos
/
Hidróxido de Alumínio
/
Hidróxido de Magnésio
/
Antiácidos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França