The effect of rifampicin on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides.
J Antimicrob Chemother
; 37(5): 993-8, 1996 May.
Article
em En
| MEDLINE
| ID: mdl-8737149
ABSTRACT
Using the dynamic chequerboard technique, we confirmed that rifampicin produces a synergistic bactericidal effect when combined with amikacin or netilmicin. Adaptive resistance was suppressed when rifampicin was added to aminoglycoside after, but not during, first exposure to amikacin or netilmicin. The effect of rifampicin on adaptive resistance could account for the synergy between rifampicin and aminoglycosides.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
/
Rifampina
/
Resistência Microbiana a Medicamentos
/
Aminoglicosídeos
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França