A new non-HLA multigene family associated with the PERB11 family within the MHC class I region.
Immunogenetics
; 44(4): 259-67, 1996.
Article
em En
| MEDLINE
| ID: mdl-8753856
ABSTRACT
In an effort to initiate steps designed to characterize the idiopathic hemochromatosis disease gene, the HLA-A/HLA-F region where this gene is in disequilibrium linkage with some polymorphic markers has been overlapped by a yeast artificial chromosome (YAC) contig. In order to achieve the physical mapping of these YACs and of the corresponding genomic region, we subcloned one of the YACs involved. A computer-assisted analysis of the sequence of one subclone led to the isolation of a potential exon that proved to belong to a new expressed messenger named HCGIX. After Southern blot analysis, the corresponding cDNA clone was found to belong to a new multigene family whose members are dispersed throughout the HLA class I region and are closely associated with members of another recently described multigene family designated PERB11. The data reported here suggest that these two multigene families form a cluster that have been dispersed together throughout the telomeric part of the major histocompatibility complex and have been involved in the genesis of this human class I region.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genes MHC Classe I
/
Família Multigênica
/
Mapeamento Cromossômico
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Immunogenetics
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França