Early efficacy of liposomal amphotericin B in the treatment of visceral leishmaniasis.
Trans R Soc Trop Med Hyg
; 90(3): 317-8, 1996.
Article
em En
| MEDLINE
| ID: mdl-8758092
ABSTRACT
The rapidity and efficacy of a short course of liposomal amphotericin B was evaluated in 29 children affected by visceral leishmaniasis (Leishmania infantum). Their overall health status was assessed using the prognostic inflammatory and nutritional index (PINI), and their haematological status by the reticulocyte count and haemoglobin blood levels. All these quantities were measured on day 0, and 3 and 10 d after starting therapy. A significant decrease of inflammatory signs, associated with an improved reticulocyte count, was recorded after 3 d of therapy. A significant increase of haemoglobin levels was also observed 10 d after the start of treatment. The early reduction of inflammatory signs and the improvement of bone marrow function in most patients confirmed the validity of amphotericin B therapy. The PINI score is helpful in assessing the severity of visceral leishmaniasis and the follow-up of its treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anfotericina B
/
Leishmania infantum
/
Leishmaniose Visceral
/
Antiprotozoários
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália