Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro.
Biochim Biophys Acta
; 1308(3): 256-62, 1996 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-8809118
ABSTRACT
The in vitro relationship between eukaryotic DNA polymerases and fatty acids was investigated. Some fatty acids strongly inhibited the activities of DNA polymerase alpha and/or beta in vitro. The kinetics of inhibition by linoleic acid showed that DNA polymerase alpha was non-competitively inhibited with respect to the DNA template and substrate (dTTP), while DNA polymerase beta was inhibited competitively with both DNA and substrate.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Síntese de Ácido Nucleico
/
Ácidos Graxos
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão