Inhibitory effects of selenium, vitamin A and butylated hydroxytoluene on growth of human maxillary cancer cells in vitro.
Auris Nasus Larynx
; 23: 91-7, 1996.
Article
em En
| MEDLINE
| ID: mdl-8809329
ABSTRACT
The effects of vitamin A, selenium, and butylated hydroxytoluene (BHT) on the growth of a human maxillary cancer cell line were examined in monolayer cell cultures. The colony-forming assay showed a 50% reduction in the survival rate of the cell line at a concentration of 3.6 micrograms/ml of selenium, 28 micrograms/ml of vitamin A, and 74 micrograms/ml of BHT. Flow cytometric analysis with both FITC-labeled bromodeoxyuridine monoclonal antibody and propidium iodide demonstrated an increase of the S-phase fraction in the presence of selenium, an increase of the G0/G1-phase fraction in the presence of vitamin A, and an increase of the G2-M-phase fraction 1 day followed by an increase of G0/G1-phase fraction from the 3rd to 7th day when BHT was added. These results suggest that the mechanisms of inhibition of DNA synthesis by these compounds are different.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selênio
/
Vitamina A
/
Hidroxitolueno Butilado
/
Neoplasias Maxilares
/
Maxila
Limite:
Humans
Idioma:
En
Revista:
Auris Nasus Larynx
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Japão