Tumor necrosis factor receptor p55 mediates induction of HIV type 1 expression in chronically infected U1 cells.
AIDS Res Hum Retroviruses
; 12(3): 199-204, 1996 Feb 10.
Article
em En
| MEDLINE
| ID: mdl-8835197
ABSTRACT
Tumor necrosis factor alpha (TNF-alpha) is a potent inducer of human immunodeficiency virus type 1 (HIV-1) expression in chronically infected cells. The aim of this study was to investigate the role played by the two known TNF-alpha receptors, TNFR-p55 and TNFR-p75, in the activation of HIV-1 expression. As a model system the latently infected human promonocytic cell line U1 was stimulated with wild-type TNF-alpha, with TNF-alpha muteins that specifically bind to one or the other receptor or with receptor-specific monoclonal antibodies. Induction of HIV-1 expression, measured by p24 core antigen capture enzyme-linked immunosorbent assay (ELISA), was found to be exclusively triggered by TNFR-p55 stimulation. However, our results also showed that the addition of TNFR-p75-specific ligands negatively modulated the HIV-1 expression induced via TNFR-p55.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monócitos
/
Antígenos CD
/
HIV-1
/
Fator de Necrose Tumoral alfa
/
Proteína do Núcleo p24 do HIV
/
Receptores do Fator de Necrose Tumoral
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Suíça