Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy.
J Intern Med
; 240(3): 161-4, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8862126
ABSTRACT
The first case of cobalamin deficiency with megaloblastic anaemia in a patient under long-term omeprazole therapy is presented. This patient received omeprazole at a daily dose of 40-60 mg for 4 years as treatment for a gastro-oesophagal reflux complicated by peptic oesophagitis. Seric vitamin B12 was dramatically decreased at 80 pmol L-1. The Schilling test was normal (13%) with crystalline [57Co] cobalamin and it was at 0% with [57Co] cobalamin-labelled trout meat. All other assimilation tests were normal except an expiratory hydrogen breath test performed with lactulose. The haematological status was restored after intramuscular treatment with cobalamin. In conclusion, prolonged omeprazole therapy can be responsible for a cobalamin deficiency due to protein-bound cobalamin malabsorption.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina B 12
/
Omeprazol
/
Inibidores Enzimáticos
/
Anemia Megaloblástica
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França