Schwann cell differentiation.
Curr Opin Cell Biol
; 8(6): 870-6, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8939676
ABSTRACT
Recent studies of Schwann cell differentiation in vivo and in vitro have provided new insights into determinative signal transduction events both at the cell surface and in the nucleus. Several polypeptide growth factors and their receptors, most notably the neuregulins and receptors of the ErbB family, have been implicated in the specification of cell fate, the control of precursor cell proliferation, and the regulation of programmed cell death during both early and late Schwann cell differentiation. Our understanding of the transcriptional control of Schwann cell development, particularly by the POU protein SCIP and the zinc-finger protein Krox-20, has been advanced by transgenic, knockout, and expression studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células de Schwann
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos