Immunohaematological findings in healthy and HIV-1 infected adults in Dar es Salaam, Tanzania.
East Afr Med J
; 73(10): 670-4, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8997848
ABSTRACT
PIP: Lymphocyte subsets and concentrations of beta-2 microglobulin (B2M) were determined among 119 HIV-1 seronegative and 183 HIV-1 seropositive individuals at Muhimbili Medical Center (MMC) to assess their prognostic value in HIV-1 infected Tanzanian patients. The HIV-negative individuals were blood donors at MMC, while the HIV-positive participants were blood donors, patients admitted to one medical ward, and those seen at MMC's outpatient clinic who were found to be HIV-positive during the study period. HIV-negative blood donors were of mean age 28.8 years and patients were of mean age 33.5. The measurement of peripheral white blood cell (WBC) count, total lymphocytes, CD4 and CD8 T-lymphocytes, and B2M concentrations found CD4 T-lymphocytes, CD8 T-lymphocyte percentages, CD4:CD8 lymphocyte ratios, and the concentrations of B2M to be strongly correlated with the clinical stages of HIV-1 infection. These findings suggest that B2M could be a useful prognostic marker in HIV-1 infection in settings where T-lymphocyte subset determinations cannot be made.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Subpopulações de Linfócitos
/
Microglobulina beta-2
/
HIV-1
/
Relação CD4-CD8
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
East Afr Med J
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Tanzânia