The effect of iodine-based contrast agents on the levels of radiation-induced chromosomal aberrations.
Radiat Res
; 147(2): 263-8, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9008219
ABSTRACT
The effects of iodine-based contrast agents on the repair of radiation-induced chromosomal damage were investigated employing peripheral blood from a healthy male donor. The blood samples were irradiated with 0.5-4.0 Gy 137Cs gamma rays. Contrast agents and NaCl solutions of various concentrations were added to the blood within the first 15 min or at 60 min after irradiation, and the samples were subsequently cultured for 45 h at 37 degrees C. Significantly elevated frequencies of chromosomal abnormalities caused by postirradiation treatment with hypertonic contrast agents appeared to increase with increasing hypertonicity. Elevated aberration frequencies were found to be greatest in the samples treated within 15 min of irradiation. The contrast agents had little effect if they were added at 60 min after irradiation, probably because the process of chromosome rejoining had been completed. Isotonic iodine-based contrast agents did not enhance the frequencies of chromosomal aberrations to a significant degree.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Ácidos Tri-Iodobenzoicos
/
Iopamidol
/
Linfócitos
/
Aberrações Cromossômicas
/
Cromossomos Humanos
/
Meios de Contraste
/
Diatrizoato
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Reparo do DNA
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Soluções Hipertônicas
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Radiat Res
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão