Recognition of telomeric DNA.
Trends Biochem Sci
; 22(2): 43-7, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9048479
ABSTRACT
The three-dimensional structure of the yeast telomere-binding protein RAP1 in complex with DNA provides the first insight into telomeric DNA recognition. RAP1 binds to DNA via two Myb/homeodomain-like motifs, which are DNA-binding folds previously identified in transcription factors. This, together with the finding that human TRF1 and other telomere-binding factors contain Myb-like motifs, has led us to speculate that a conserved protein fold might be used for telomeric DNA recognition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Telômero
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido