Membranous nephropathy in primary antiphospholipid syndrome: description of a case and induction of renal injury in SCID mice.
Hum Antibodies Hybridomas
; 7(3): 91-6, 1996.
Article
em En
| MEDLINE
| ID: mdl-9057056
ABSTRACT
Primary antiphospholipid syndrome (PAPS) is a recently recognized clinical entity encompassing the combination of thromboembolic phenomena, thrombocytopenia and recurrent abortions in the presence of antiphospholipid antibodies. We present a patient with PAPS accompanied by renal involvement, manifested as membranous nephropathy, as proven by a renal biopsy. To investigate further the possible association between PAPS and the renal lesions we attempted to induce similar renal manifestations by transferring peripheral blood lymphocytes (PBL) from this patient to severe combined immunodeficiency (SCID) mice. The mice transfused with PBL from the affected patient exemplified antiphospholipid antibodies (aPL) following which a renal lesion consistent with the human membranous nephropathy lesion was precipitated. This study substantiates the role of aPL as possible inducers of renal damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glomerulonefrite Membranosa
/
Síndrome Antifosfolipídica
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Hum Antibodies Hybridomas
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Israel