Absence of rebound effect with calcium carbonate.
Eur J Drug Metab Pharmacokinet
; 21(4): 351-7, 1996.
Article
em En
| MEDLINE
| ID: mdl-9074901
ABSTRACT
This was an open, randomised balance cross-over study in 12 healthy male volunteers. The antacid activity of calcium carbonate plus magnesium carbonate (Rennie and hydrotalcite (Talcid), given in the recommended dose of 2 tablets 4 times daily, were compared using 24 h intragastric measurement of pH. The volunteers received 2 tablets of calcium carbonate plus magnesium carbonate or hydrotalcite according to a randomised order 1 h after each meal and at bedtime. Results showed that both treatments have similar antacid efficacy and a similar duration of action of about one hour. There was no evidence of acid 'rebound' following either treatment during the second and third hours following the administration of antacid.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbonato de Cálcio
/
Mucosa Gástrica
/
Magnésio
/
Antiácidos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Drug Metab Pharmacokinet
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França