NMR evidence for slow collective motions in cyanometmyoglobin.
Nat Struct Biol
; 4(4): 292-7, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9095197
ABSTRACT
Residual dipolar couplings observed in NMR spectra at very high magnetic fields have been measured to a high degree of accuracy for the paramagnetic protein cyanometmyoglobin. Deviations of these measurements from predictions based on available crystallographic and solution structures are largely systematic and well correlated within a given helix of this highly alpha-helical protein. These observations can be explained by invoking collective motion and small displacements of representative helices from their reported average positions in the solid state. Thus, the measurements appear to be capable of providing important insights into slower, collective protein motions, which are likely to be important for function, and which have been difficult to study using established experimental techniques.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metamioglobina
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Nat Struct Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos