Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
Nature
; 386(6627): 796-804, 1997 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-9126737
ABSTRACT
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
/
Genes DCC
/
Mutagênese
/
Proteínas Supressoras de Tumor
/
Neoplasias Intestinais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nature
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos