Association of hepatic necrosis with trimethoprim sulfonamide administration in 4 dogs.
J Vet Intern Med
; 11(1): 20-3, 1997.
Article
em En
| MEDLINE
| ID: mdl-9132479
ABSTRACT
Hepatic necrosis in association with trimethoprim-sulfonamide (TMS) combination therapy was diagnosed in 4 dogs based on history, clinical presentation, and examination of histopathologic specimens collected postmortem. Duration of TMS therapy prior to onset of clinical signs ranged from 4 to 30 days. The dose of TMS ranged from 18 mg/kg to 53 mg/kg bid. Despite supportive medical therapy, all dogs died or were euthanized due to hepatic failure. This report highlights the potential for hepatotoxicity during TMS therapy. Duration of therapy, type of TMS combination, and dose did not appear related to the development of toxicity. The low number of dogs affected suggests an idiosyncratic drug reaction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trimetoprima
/
Doenças do Cão
/
Hepatopatias
/
Anti-Infecciosos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Vet Intern Med
Assunto da revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos