Stobadine pretreatment enhances glutathione peroxidase activity in the heart of irradiated mice.
Methods Find Exp Clin Pharmacol
; 19(4): 241-3, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9228649
ABSTRACT
The effect of pretreatment with stobadine (a novel drug with cardioprotective properties) on the activity of glutathione peroxidase was studied in the heart of mice after Co60 irradiation. Exposure to 6.5 Gy caused significant decrease in the activity of the enzyme (p < 0.01). Treatment with stobadine (70.07 mg/kg) 1 or 2 h before irradiation resulted in activity enhancement in comparison with the nonpretreated irradiated group (p < 0.01). We conclude that the radical scavenging mechanism may be involved in the protection exerted by stobadine. The results are in agreement with those obtained by the micronucleus test.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protetores contra Radiação
/
Carbolinas
/
Glutationa Peroxidase
/
Coração
/
Antiarrítmicos
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Methods Find Exp Clin Pharmacol
Ano de publicação:
1997
Tipo de documento:
Article