Relevance of Na,K-ATPase to local extracellular potassium homeostasis and modulation of synaptic transmission.
FEBS Lett
; 412(1): 1-4, 1997 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-9257678
ABSTRACT
The ion gradients generated by the Na,K-ATPase are essential for Na+-coupled transport systems, osmoregulation and restoration of ion concentrations in excitable tissues. Indirectly, the sodium pump controls intracellular Ca2+ concentration through the Na/Ca exchanger. In the nervous system various neurotransmitters can modulate Na,K-ATPase activity. The great diversity of Na,K-ATPase subunit isoforms, their complex spatial and temporal regulation of expression and their cellular localisation imply a functional role of the sodium pump in different regulatory pathways. Among these, potassium homeostasis and modulation of synaptic transmission are discussed here.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potássio
/
ATPase Trocadora de Sódio-Potássio
/
Transmissão Sináptica
/
Homeostase
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1997
Tipo de documento:
Article