N-methyl-D-aspartate receptor binding in brains of rats at different ages.
Neurobiol Aging
; 18(3): 329-33, 1997.
Article
em En
| MEDLINE
| ID: mdl-9263199
ABSTRACT
Potential age differences in N-methyl-D-aspartate (NMDA) receptor binding were evaluated in rat brain using [3H]dizocilpine and [3H]D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentanoic acid (CGP 39653) as the radioligands. Neither [3H]dizocilpine nor [3H]CGP 39653 binding in hippocampus revealed any age difference (7 vs. 23-25 months) in Bmax or Kd. High-affinity [3H]dizocilpine binding showed a developmental increase (8 vs. 2 months) in hippocampus but not in frontal cortex. No senescence-related change (25 vs. 8 months) was observed in either region. The lack of senescence-related differences in these biochemical markers does not preclude the possibility of functional changes in the NMDA receptor with aging.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Envelhecimento
/
Receptores de N-Metil-D-Aspartato
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos