Mannan-binding lectin serum concentrations in HIV-infected patients are influenced by the stage of disease.
Immunol Lett
; 58(3): 171-5, 1997 Aug.
Article
em En
| MEDLINE
| ID: mdl-9293399
ABSTRACT
Serum concentrations of mannan-binding lectin (MBL) were determined in the sera of 67 HIV-seropositive patients in different stages of HIV disease and in the sera of 75 HIV-seronegative healthy individuals. In the asymptomatic (AS) HIV-infected persons MBL concentrations were found to be significantly (P < 0.05) lower than in the HIV-seronegative controls, whereas in the AIDS patients they were not. Very low (< or = 25 ng/ml) MBL serum concentrations were detected in 5/19 (26.3%) and 7/75 (9.3%) of the AS HIV-seropositive and HIV-seronegative individuals, respectively (P = 0.06). In the sera of the HIV-infected patients, MBL levels positively correlated to the neopterin concentrations (Spearman correlation coefficient, 0.401, P = 0.0009) while they negatively correlated to the percentage (-0.447, P = 0.0011) and absolute number (-0.453, P = 0.0012) of the CD4+ lymphocytes. These observations indicate that MBL level, which is under strict genetic control, may influence the susceptibility to HIV infection and the progression of HIV disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Sanguíneas
/
Proteínas de Transporte
/
Infecções por HIV
/
Lectinas
/
Mananas
Limite:
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Hungria