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Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b).
Moreau, E J; Matutes, E; A'Hern, R P; Morilla, A M; Morilla, R M; Owusu-Ankomah, K A; Seon, B K; Catovsky, D.
Afiliação
  • Moreau EJ; Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, England.
Am J Clin Pathol ; 108(4): 378-82, 1997 Oct.
Article em En | MEDLINE | ID: mdl-9322589
A scoring system, based on the immunophenotypic analysis of a panel of five membrane markers (CD5, CD22, CD23, FMC7, SmIg) was shown to be useful in the distinction between chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative diseases (non-CLL). We investigated whether the monoclonal antibody SN8 (CD79b) could improve our previous scoring system. Peripheral blood samples of 298 patients with CLL and 166 patients with non-CLL were analyzed by flow cytometry. Using the five standard markers, the accuracy of the scoring system was 91.8%, using a cutoff of 4 points or higher, to distinguish CLL from non-CLL. This was increased to 96.6% if SN8 was added and a cutoff of 4 points or higher was also used. A similar accuracy, 96.8%, was observed if CD22 was excluded and a cutoff of 3 points or higher was used. Thus, the replacement of CD22 by SN8 in the original scoring system significantly increases its potential to discriminate between CLL and other B-cell lymphoproliferative diseases.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Antígenos CD / Imunofenotipagem / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Am J Clin Pathol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Reino Unido
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Antígenos CD / Imunofenotipagem / Anticorpos Monoclonais Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Am J Clin Pathol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Reino Unido