Clearance of Wuchereria bancrofti antigen after treatment with diethylcarbamazine or ivermectin.
Am J Trop Med Hyg
; 57(4): 483-6, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9347968
ABSTRACT
The present study was undertaken to assess the relationship between microfilarial clearance and clearance of circulating filarial antigen from the blood of Wuchereria bancrofti-infected persons following chemotherapy with either diethylcarbamazine or ivermectin. Patients received either 12 weekly doses of 6 mg/kg of diethylcarbamazine (DEC), a single dose of 6 mg/kg of DEC, a single dose of 420 microg/kg of ivermectin, or 20 microg/kg of ivermectin, followed by 6 mg/kg of DEC five days later. Microfilarial clearance was marked in all groups, but was significantly less in the single-dose DEC. In contrast, as monitored by the Og4C3 monoclonal anitbody assay, clearance of circulating filarial antigen was highly variable, not only between groups but within each group. As a result, there were few statistically significant differences in antigen clearance between groups. In no instance did the antigen level fall to zero, even in individuals that remained microfilaria negative during two or three years of follow-up. These results suggest that living adult worms persist in almost all persons treated with DEC and/or ivermectin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Wuchereria bancrofti
/
Ivermectina
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Dietilcarbamazina
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Filariose
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Filaricidas
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Antígenos de Helmintos
Limite:
Adolescent
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Adult
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Aged
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Animals
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos