Gastrin-releasing peptide stimulates possum gallbladder contractility in vitro.
Peptides
; 18(7): 1067-71, 1997.
Article
em En
| MEDLINE
| ID: mdl-9357068
ABSTRACT
Reports of the action of gastrin-releasing peptide (GRP) on gallbladder contraction are limited to a few species. We compared the action of GRP, acetyl gastrin-releasing peptide 20-27 (GRP 20-27), and cholecystokinin-octapeptide (CCK-8) on gallbladder contractility with and without pretreatment with the neural inhibitor tetrodotoxin (TTX) and the bombesin antagonist [D-Phe 6, Des-Met 14]-bombesin 6-14 ethylamide (BBS 6-14 E). Full-thickness muscle strips were prepared and suspended in organ baths. The maximum GRP, GRP 20-27, and CCK-8 responses were 54.2 +/- 4.2%, 74.6 +/- 6.4%, and 69.3 +/- 6.9% of that of carbachol, respectively. Pretreatment with TTX influenced the action of GRP 20-27, and pretreatment with BBS 6-14 E influenced that of GRP and GRP 20-27. These studies show that GRP and GRP 20-27 are potent agonists of gallbladder contractility, acting via GRP-preferring receptors, and that GRP 20-27 also acts via a neural component.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Liberador de Gastrina
/
Vesícula Biliar
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Austrália