Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.
Science
; 279(5352): 863-7, 1998 Feb 06.
Article
em En
| MEDLINE
| ID: mdl-9452386
ABSTRACT
In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta and retinoid X receptors beta and gamma resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Transdução de Sinais
/
Dopamina
/
Receptores do Ácido Retinoico
/
Corpo Estriado
/
Atividade Motora
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França