Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Nat Med
; 4(4): 447-51, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9546791
ABSTRACT
Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid beta-amyloid (Abeta) peptides, and autosomal dominant forms of AD appear to cause disease by promoting brain Abeta accumulation. Recent studies indicate that postmenopausal estrogen replacement therapy may prevent or delay the onset of AD. Here we present evidence that physiological levels of 17beta-estradiol reduce the generation of Abeta by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons. These results suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Peptídeos beta-Amiloides
/
Precursor de Proteína beta-Amiloide
/
Estradiol
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos