Tardive dyskinesia in dopa-responsive dystonia: a reappraisal of the dopamine hypothesis of tardive dyskinesia.
Neurology
; 50(4): 1134-5, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9566407
ABSTRACT
Dopa-responsive dystonia, an autosomal-dominant disorder caused by mutations in the guanosine triphosphate (GTP)-cyclohydrolase I gene, is characterized by severe striatal dopamine depletion. Tardive dyskinesia, on the other hand, has often been associated with striatal dopamine overactivity. This article reports on a 44-year-old man with dopa-responsive dystonia who developed tardive dyskinesia on long-term haloperidol therapy. Nigrostriatal dopamine deficiency may be necessary for the development of tardive dyskinesia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antidiscinéticos
/
Discinesia Induzida por Medicamentos
/
Distonia
/
Haloperidol
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurology
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Espanha