Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder.
Am J Psychiatry
; 155(6): 835-7, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9619160
ABSTRACT
OBJECTIVE:
The authors previously reported a relationship between an allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behavior in schizophrenic patients. This study replicates and extends these findings by using more direct measures of violent behavior.METHOD:
Fifty-five white patients (34 men, 21 women) with DSM-IV diagnoses of schizophrenia or schizoaffective disorder were selected to form two groups (violent and nonviolent) on the basis of history of aggressive behavior. COMT genotypes were determined by restriction fragment length polymorphism analysis.RESULTS:
A significant association was found between COMT genotype and history of violent behavior. Sixty-four percent of patients homozygous for the low-activity COMT allele were violent; 80% of patients homozygous for the high-activity allele were nonviolent.CONCLUSIONS:
The gene determining the activity of an important regulatory enzyme in catecholamine inactivation is associated with violent behavior in patients with schizophrenia and schizoaffective disorder.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
/
Psicologia do Esquizofrênico
/
Violência
/
Catecol O-Metiltransferase
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Psychiatry
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos