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Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder.
Lachman, H M; Nolan, K A; Mohr, P; Saito, T; Volavka, J.
Afiliação
  • Lachman HM; Department of Psychiatry and Medicine, Albert Einstein College of Medicine, Orangeburg, N.Y., USA. lachman@aecom.yu.edu
Am J Psychiatry ; 155(6): 835-7, 1998 Jun.
Article em En | MEDLINE | ID: mdl-9619160
ABSTRACT

OBJECTIVE:

The authors previously reported a relationship between an allele encoding the low activity variant of catechol O-methyltransferase (COMT) and aggressive behavior in schizophrenic patients. This study replicates and extends these findings by using more direct measures of violent behavior.

METHOD:

Fifty-five white patients (34 men, 21 women) with DSM-IV diagnoses of schizophrenia or schizoaffective disorder were selected to form two groups (violent and nonviolent) on the basis of history of aggressive behavior. COMT genotypes were determined by restriction fragment length polymorphism analysis.

RESULTS:

A significant association was found between COMT genotype and history of violent behavior. Sixty-four percent of patients homozygous for the low-activity COMT allele were violent; 80% of patients homozygous for the high-activity allele were nonviolent.

CONCLUSIONS:

The gene determining the activity of an important regulatory enzyme in catecholamine inactivation is associated with violent behavior in patients with schizophrenia and schizoaffective disorder.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / Psicologia do Esquizofrênico / Violência / Catecol O-Metiltransferase Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Psychiatry Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Esquizofrenia / Psicologia do Esquizofrênico / Violência / Catecol O-Metiltransferase Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Psychiatry Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos