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Clinical, neurophysiological, and magnetic resonance imaging correlations in multiple sclerosis.
Comi, G; Filippi, M; Rovaris, M; Leocani, L; Medaglini, S; Locatelli, T.
Afiliação
  • Comi G; Department of Clinical Neurophysiology, University of Milan, Scientific Institute H San Raffaele, Italy.
J Neurol Neurosurg Psychiatry ; 64 Suppl 1: S21-5, 1998 May.
Article em En | MEDLINE | ID: mdl-9647280
Magnetic resonance imaging (MRI) has a pivotal role in diagnosis of multiple sclerosis and is being increasingly used as a paraclinical measure to assess treatment efficacy in clinical trials. However, the correlations between clinical and MRI findings in patients with multiple sclerosis are weak and, therefore, newer MR techniques are being developed to increase both MRI sensitivity for detecting disease activity and its pathological specificity for better assessing disease evolution. Evoked potentials (EPs) can be used to confirm the diagnosis of multiple sclerosis and their abnormalities are correlated with symptoms and signs referable to involvement of the corresponding nervous pathways. However, their use is limited when assessing disease progression and monitoring clinical trials in multiple sclerosis. Both magnetic resonance imaging (MRI) and evoked potentials (EPs) provide information which cannot be obtained by clinical evaluation, especially for assessing disease activity. Nevertheless, both these paraclinical techniques cannot substitute for clinical measures of disability when assessing disease progression and monitoring phase III clinical trials in multiple sclerosis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética / Esclerose Múltipla Limite: Humans Idioma: En Revista: J Neurol Neurosurg Psychiatry Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Itália
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética / Esclerose Múltipla Limite: Humans Idioma: En Revista: J Neurol Neurosurg Psychiatry Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Itália