Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.
FEBS Lett
; 435(2-3): 225-8, 1998 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-9762914
ABSTRACT
Brush border lactase-phlorizin hydrolase carries two catalytic sites. In the human enzyme lactase comprises Glu-1749, phlorizin hydrolase Glu-1273. The proteolytic processing of pro-lactase-phlorizin hydrolase by (rat) enterocytes stops two amino acid residues short of the N-terminus of 'mature' final, brush border lactase-phlorizin hydrolase. Only these two amino acid residues are removed by luminal pancreatic protease(s), probably trypsin.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Lactase-Florizina Hidrolase
/
Intestinos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1998
Tipo de documento:
Article