Modelling the mechanical properties of cardiac muscle.
Prog Biophys Mol Biol
; 69(2-3): 289-331, 1998.
Article
em En
| MEDLINE
| ID: mdl-9785944
ABSTRACT
A model of passive and active cardiac muscle mechanics is presented, suitable for use in continuum mechanics models of the whole heart. The model is based on an extensive review of experimental data from a variety of preparations (intact trabeculae, skinned fibres and myofibrils) and species (mainly rat and ferret) at temperatures from 20 to 27 degrees C. Experimental tests include isometric tension development, isotonic loading, quick-release/restretch, length step and sinusoidal perturbations. We show that all of these experiments can be interpreted with a four state variable model which includes (i) the passive elasticity of myocardial tissue, (ii) the rapid binding of Ca2+ to troponin C and its slower tension-dependent release, (iii) the kinetics of tropomyosin movement and availability of crossbridge binding sites and the length dependence of this process and (iv) the kinetics of crossbridge tension development under perturbations of myofilament length.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coração
/
Modelos Cardiovasculares
/
Contração Miocárdica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Prog Biophys Mol Biol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Nova Zelândia