Proteasome inhibitors: valuable new tools for cell biologists.
Trends Cell Biol
; 8(10): 397-403, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9789328
ABSTRACT
Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome inhibitors has allowed a definition of the roles of the ubiquitin-proteasome pathway in various cellular processes, such as antigen presentation and the degradation of regulatory or membrane proteins. This review describes the actions of these inhibitors, how they can be used to investigate cellular responses, the functions of the proteasome demonstrated by such studies and their potential applications in the future.
Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Inibidores de Proteases
/
Cisteína Endopeptidases
/
Proteínas
/
Complexos Multienzimáticos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos