Effect of phencyclidine on dog coronary artery.
Zhongguo Yao Li Xue Bao
; 17(3): 224-6, 1996 May.
Article
em En
| MEDLINE
| ID: mdl-9812741
ABSTRACT
AIM:
To study the effect of phencyclidine (Phe) on dog coronary artery.METHODS:
Contraction of spiral strips of dog coronary artery in bioassay and coronary artery blood flow (CBF) using electromagnetic flowmeter on anesthetized dogs were observed.RESULTS:
Phe 0.1-100 mumol.L-1 induced contraction of strips in a concentration-dependent manner. Dextromethorphan (Dex) 10 mumol.L-1, an antagonist of Phe receptor, antagonized the action of Phe. In vivo, Phe 10 mg.kg-1 increased flow of left circumflex coronary artery of anesthetized dogs from 334 +/- 35 mL.kg-1.min-1 to 510 +/- 58 mL.kg-1.min-1, and both left ventrical pressure (LVP) and blood pressure (BP) rose slowly after medication. Dextromethorphan (Dex) 5 mg.kg-1 also antagonized the effect of Phe.CONCLUSION:
The regulation of Phe on coronary artery in vivo differs from that in vitro, which may result in the contradictory effects.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenciclidina
/
Circulação Coronária
/
Contração Muscular
/
Músculo Liso Vascular
Limite:
Animals
Idioma:
En
Revista:
Zhongguo Yao Li Xue Bao
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
China